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. 2023 Sep 21;4(9):1345–1361. doi: 10.1038/s43018-023-00630-y

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 1 — We performed kinase selectivity profile across 256 kinases in the presence of (a) 22 nM selpercatinib (b) 17 nM pralsetinib or (c) 26 nM TPX-0046/enbezotinib. These concentrations are approximately 100-fold higher than the corresponding IC₅₀ value for inhibition of RET^WT enzymatic activity. Kinases that were inhibited by ≥50% by each small molecule are plotted as a circle on the kinome tree in the respective panel.