. 2023 Mar 7;19(3):440–451. doi: 10.1007/s12024-023-00578-6

Table 3.

PEP regimen and alternative treatment regimen recommended by CDC

Population	PEP regimen(preferred)	Alternative regimen
Adults and adolescents (≥ 13 years) with normal renal function (Cr _CL ≥ 60 mL/min)	Tenofovir disoproxil fumarate 300 mg once daily or emtricitabine 200 mg once daily + Dolutegravir 50 mg once daily or Raltegravir 400 mg twice daily	Tenofovir disoproxil fumarate 300 mg once daily or emtricitabine 200 mg once daily + Darunavir 800 mg (as two, 400-mg tablets) once daily and ritonavirb 100 mg once daily
Adults and adolescents (≥ 13 years) with renal dysfunction (Cr _CL ≤ 59 mL/min)	Zidovudine and Lamivudine, with both doses adjusted to degree of renal function + Raltegravir 400 mg twice daily + Dolutegravir 50 mg once daily or Raltegravir 400 mg twice daily	Zidovudine and Lamivudine, with both doses adjusted to degree of renal function + Darunavir 800 mg (as two 400-mg tablets) once daily + Ritonavirb 100 mg once daily
Children aged 2–12 years	Tenofovir DF, emtricitabine, and Raltegravir, with each drug dosed to age and weight	Zidovudine and Lamivudine + Raltegravir or lopinavir/ritonavir + Raltegravir (lopinavir/ritonavir dosed to age and weight)

Population

PEP regimen(preferred)

Alternative regimen

Adults and adolescents (≥ 13 years) with normal renal function (Cr _CL ≥ 60 mL/min)

Tenofovir disoproxil fumarate 300 mg once daily or emtricitabine 200 mg once daily

Dolutegravir 50 mg once daily

Raltegravir 400 mg twice daily

Tenofovir disoproxil fumarate 300 mg once daily or emtricitabine 200 mg once daily

Darunavir 800 mg (as two, 400-mg tablets) once daily and ritonavirb 100 mg once daily

Adults and adolescents (≥ 13 years) with renal dysfunction (Cr _CL ≤ 59 mL/min)

Zidovudine and Lamivudine, with both doses adjusted to degree of renal function

Raltegravir 400 mg twice daily

Dolutegravir 50 mg once daily or Raltegravir 400 mg twice daily

Zidovudine and Lamivudine, with both doses adjusted to degree of renal function

Darunavir 800 mg (as two 400-mg tablets) once daily

Ritonavirb 100 mg once daily

Children aged 2–12 years

Tenofovir DF, emtricitabine, and Raltegravir, with each drug dosed to age and weight

Zidovudine and Lamivudine

Raltegravir or lopinavir/ritonavir

Raltegravir (lopinavir/ritonavir dosed to age and weight)

Cr _CL, creatinine clearance