TABLE 1.

Updated or new features in Ebisu.

Updated or new feature	Description
Multilingual support	Studies can be configured to set which languages they support to allow participants to view content in their preferred language.
Biofluid collection capabilities	Software features facilitate collection of saliva and blood samples.29,36  Participants may provide a shipping address and receive a saliva collection kit or be provided with information to visit a local Quest Patient Service Center to have their blood drawn. A Vendor Portal allows fulfillment vendors to log in and download spreadsheets with participant information to create orders and send out saliva kits. The vendors can upload spreadsheets with additional information related to the kits that were sent out. Saliva and blood samples are returned to the BHR specimen bank and shipped out to labs for processing information related to the status of the received samples and can be uploaded into Ebisu. Ebisu captures/monitors data concerning shipment status, collection status, and analysis status. These results are automatically imported into the BHR database, where they are combined with online data collected in BHR.
Payment log	This facilitates disbursement of participant payments upon various events, including task completion, visit completion, and study completion.
Customizable registration page for coenrollments	The software tool for enrolling existing clinical cohorts from other studies into BHR with data linkage now contains a feature for a separate, customizable registration page to join BHR with a study-specific data-sharing consent form. This feature uses the existing BHR protocol and content, thereby reducing effort for new protocol development.
New interface for datasets	Anewinterfaceallows BHR staff to easily build customizable datasets, view the history of a dataset build, and specify data as “identifiable” (Protected Health Information).The interface also allows collaborators to securely download datasets directly from the investigator portal, instead of utilizing a third-party provider for data transfers. The “master data dictionary,” a consolidated list of all variables within a dataset, greatly facilitates data analysis.
New in-clinic data collection features	For projects with in-clinic components, Ebisu schedules in-clinic appointments and manages the collection of in-clinic data. Reports are provided for upcoming and overdue in-clinic appointments. In-clinic data are linked to any corresponding data collected online at home. In-clinic data collection may also include online tasks, to be conducted in a web browser at the clinic without requiring a participant to log in, but instead using a participant-specific appointment code to navigate to the online tasks. This system is used for a current study developing and validating electronic versions of the Clinical Dementia Rating and Financial Capacity Instrument-Short Form.21
Enhanced marketing features	New features include the ability to gather and integrate data from Facebook and Google Adwords to analyze advertising efforts to recruit participants.
Redesigned user experience	To enhance the user experience and reduce subject burden, the following features were included: new color scheme, easier navigation and management of main study and substudies, participant-facing messaging with encouragements and guidance points, new task flow with balancing of activity types.