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. 2023 Sep 24;4(5):e374. doi: 10.1002/mco2.374

FIGURE 2.

FIGURE 2

Schematic illustration of the different pyroptosis pathways. At present, there are mainly four distinct signaling pathways that have been identified to induce pyroptosis, including the classical caspase 1‐dependent pathway, which depend on the inflammasomes, nonclassical caspase 4/5/11‐dependent pathway, caspase 3/caspase 8‐mediated pathway, and granzymes‐mediated pathway. DAMP, danger‐associated molecular patterns; PAMP, pathogen‐associated molecular patterns; LPS, lipopolysaccharide; IL‐1β, interleukin‐1β; IL‐18, interleukin‐18; LDH, lactate dehydrogenase; HMGB1, high mobility group box 1; GZMA, granzyme A; GZMB, granzyme B; GBP, guanylate‐binding proteins; TNF, tumor necrosis factor; IFN‐γ, interferon‐γ; IFNGR, IFN‐gamma receptor; Cyc‐c, cytochrome c; NK, natural killer cells; CTL, cytotoxic T lymphocytes.