TABLE 1.

The role of inflammasomes and pyroptosis‐related proteins in in immunity.

Inflammasomes or pyroptosis‐related proteins	Role in immunity	References
NLRP3	Invasion of TAMs, MDSCs↑ Suppressant elevated CD8+ and CD4+ T cells infiltration	7 , 78
NLRP1	Response of Th1 cells ↑ Infiltration of T and NK cells ↑	79
NLRC4	Essential for CD8+ T cells, CD4+ T cells and TAMs	80
AIM2	Treg↑ CD4+ effector T cells↓	82
IL‐1β	Th1 cells, Th17 cells↑, TAMs↑, MDSC↑ DC↑	89 , 90 85 92 , 93
IL‐18	Immune response↑ : Th1 cells response↑, IFN‐γ↑ Immune response↓: M‐MDSCs↑, IFN‐γ↓	94 95
HMGB1	Trigger dendritic cell tumor antigen processing *MDSCs↑	101 102
GSDME	NK cells, CD8+ T cells and TAMs ↑ *cytotoxic T lymphocytes	57 105