Table 2.
Logistic regression analysis for late radiation-related toxicity of both groups, with and without SIPTW.
| Incidence late toxicity |
Without SIPTW |
After SIPTW |
||||
|---|---|---|---|---|---|---|
| ADMIRE | Control | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Any late Grade 3 toxicity | 7 (35%) | 12 (18%) | 2.47 (0.81–7.5) | 0.11 | 5.09 (1.64–15.8) | 0.005 |
| Any late Grade ≥ 2 toxicity | 12 (60%) | 28 (42%) | 2.09 (0.76–5.78) | 0.16 | 3.67 (1.2–11.17) | 0.02 |
| Overall late Grade 3 dysphagia | 5 (25%) | 9 (13%) | 2.15 (0.63–7.36) | 0.22 | 3.42 (1–11.72) | 0.05 |
| Grade 3 dysphagia > 3 months | 4 (20%) | 9 (13%) | 1.61 (0.44–5.92) | 0.47 | 2.11 (0.57–7.81) | 0.26 |
| Grade 3 dysphagia > 6 months | 2 (10%) | 6 (9%) | 1.13 (0.21–6.09) | 0.89 | 2.02 (0.43–9.49) | 0.37 |
| Grade 3 dysphagia > 9 months | 1 (5%) | 3 (5%) | 1.12 (0.11–11.43) | 0.92 | 2.89 (0.45–18.62) | 0.26 |
| Grade 3 dysphagia > 12 months | 1 (5%) | 1 (2%) | 3.47 (0.21.58.18) | 0.39 | 8.16 (0.73–90.88) | 0.09 |
| Late Grade ≥ 2 dysphagia | 6 (30%) | 16 (24%) | 1.37 (0.45–4.14) | 0.58 | 1.86 (0.6–5.75) | 0.28 |
| Late Grade ≥ 2 dry mouth | 4 (20%) | 12 (18%) | 1.15 (0.32–4.04) | 0.83 | 1.27 (0.36--4.52) | 0.71 |
| Persistent laryngeal edema > 6 months | 5 (25%) | 4 (6%) | 5.25 (1.26–21.94) | 0.02 | 10.95 (2.71–44.29) | 0.001 |
| persistent mucosal ulcers > 6 months | 5 (25%) | 6 (9%) | 3.39 (0.91–12.62) | 0.07 | 4.67 (1.23–17.7) | 0.02 |
| Late Grade 3 radionecrosis | 3 (15%) | 2 (3%) | 5.74 (0.89–37.11) | 0.07 | 15.69 (2.43–101.39) | 0.004 |
Abbreviations: OR: odds ratio; CI: confidence interval; SIPTW: stabilized inverse probability of treatment weighting.