Table 2.

Significantly different (p < 0.05) protein serum levels in SSc patients compared with HC as assessed using the aptamer (SomaLogic) proteomics platform.

Increased in SSc	Reduced in SSc
Aldolase A Angiopoietin-2* C1QR1 Calpain COLEC12 Eotaxin EphA5 Fractalkine/CXCL-1 Granulins IDS Kininogen HMW LAG-3 Lamin-B1 LRP1b MATN2 MMP-12 STAT1 TNR4	Adrenomedullin ASGR1 C1s C5 Calgranulin B CD177 Desmoglein-1 Flt-3 ligand G-CFS-R IL-1Ra Leptin Lypd3 SH21A SNAP25 TPSB2

ASGR1, asialoglycoprotein receptor 1; C1QR1, complement component C1q receptor 1; C1s, complement fraction 1s; C5, complement fraction 5; COLEC12, collectin-12; EphA5, ephrin type-A receptor 5; G-CSF-R, receptor for granulocyte colony stimulating factor; HMW, high molecular weight; IDS, iduronate 2-sulfatase; IL-1Ra, interleukin-1 receptor antagonist; LAG-3, lymphocyte-activation gene 3; LRP1b, low-density lipoprotein receptor-related protein 1B; Lypd3, LY6/PLAUR domain containing 3; MATN2, matrilin 2; MMP-12, matrix metalloproteinase 12.

SH21A, SH2 domain-containing protein 1A; SNAP25, synaptosome associated protein 25; STAT1, signal transducer and activator of transcription 1; TNR4, TNF receptor superfamily member 4; TPSB2, tryptase beta-2.

* Significantly increased also at ELISA validation (p < 0.0001).