Table 3.

Significantly different (p < 0.05) protein serum levels in SSc with ILD compared with SSc without ILD and HC as assessed using SomaLogic proteomics.

Increased in SSc-ILD	Reduced in SSc-ILD
FCRL3 IL-22BP** MCP-3 PDE11 PGP9.5 sICAM-5 Stratifin	BAFF DERM

BAFF, B cell activating factor; DERM, dermatopontin; FCRL3, Fc receptor-like protein 3; IL-22BP, interleukin-22 binding protein; MCP-3, human monocyte chemotactic protein-3; PDE11, phosphodiesterase 11; PGP9.5, protein gene product 9.5; sICAM-5, soluble intercellular adhesion molecule 1.

**Significantly increased also at ELISA validation comparing patients with SSc-ILD and HC (p < 0.0001).