Table 4.
Serum concentration -median (IQR)- of validated proteins in HC, and SSc according to the presence or absence of SSc-ILD.
| HC | SSc | SSc-ILD | SSc without ILD | |
|---|---|---|---|---|
| Aldolase A | 71.9 (67.0-97.4) | 91.9 (78.3-102) | 92.6 (76.7-95.8) | 88.4 (78.3-110) |
| Ang2 | 0.58 (0.34-0.82)*° | 1.15 (0.60-2.41)* | 1.45 (0.79-3.09)° | 1.08 (0.58-2.12) |
| BAFFR | 1.04 (0.38-1.28) | 1.05 (0.64-2.38) | 0.85 (0.58-1.54) | 1.39 (0.80-2.62) |
| Calgranulin B | 24.0 (11.6-45.4) | 29.0 (16.6-65.0) | 31.4 (21.7-60.1) | 26.9 (16.6-65.0) |
| Calpain | 12.7 (11.6-13.2) | 13.4 (12.6-14.0) | 13.0 (12.1-13.7) | 13.6 (12.7-14.2) |
| CD177 | 12.3 (10.5-16.1) | 10.9 (7.28-15.5) | 10.4 (6.34-20.0) | 10.9 (7.36-14.7) |
| Eotaxin | 1.09 (0.74-1.65) | 0.94 (0.62-1.35) | 1.03 (0.56-1.36) | 0.93 (0.62-1.35) |
| Fractalkine | 2.37 (1.38-3.29) | 2.82 (1.39-3.49) | 2.37 (1.38-4.35) | 2.87 (1.39-3.49) |
| IL-22BP | 20.4 (13.9-37.6)° | 26.2 (16.1-51.0) | 36.3 (18.7-57.8)° | 24.7 (13.7-50.8) |
| Kininogen | 596 (506-765) | 522 (352-707) | 604 (299-807) | 515 (433-689) |
| Leptin | 2.11 (0.83-3.66) | 1.92 (0.60-4.10) | 2.09 (1.02-3.85) | 1.92 (0.33-4.10) |
| MMP-12 | 0.20 (0.16-0.33)*° | 0.10 (0.06-0.16)* | 0.09 (0.05-0.13)° | 0.12 (0.06-0.18) |
| TPSB2 | 42.6 (17.9-84.3) | 59.6 (23.4-123) | 67.5 (16.6-190) | 56.9 (27.2-98.3) |
HC, healthy controls; SSc-ILD, SSc-associated interstitial lung disease.
*p < 0.05 comparing SSc vs. HC.
°p < 0.05 comparing SSc-ILD vs. HC.
p > 0.05 comparing SSc without ILD vs HC.