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. Author manuscript; available in PMC: 2023 Sep 25.
Published in final edited form as: Nat Chem Biol. 2022 Oct 20;19(2):176–186. doi: 10.1038/s41589-022-01167-4

Fig. 6 ∣. PWWP domain DNA binding is required for full activity.

Fig. 6 ∣

Model showing the role of PWWP domain DNA binding in DNMT3A methylation. Top, wild-type PWWP domain binds DNA in addition to its canonical role as a H3K36me2 reader. Bottom, mutations in the PWWP domain that disrupt DNA binding, such as R301W, lead to impaired methylation while preserving H3K36me2 targeting.