Figure 1.

Overall synopsis of the plasma proteome profiling of UTUC patients

(A) The proteomics workflow involved three modules: cohort construction (discovery cohort and validation cohort), proteomic profiling, and data analysis.

(B) Pie chart showing the component proportion of UTUC discovery cohort.

(C) Clinical data of UTUC discovery cohort.

(D) Proteins identified in UTUC and normal plasma samples of UTUC discovery cohort.

(E) Number of proteins identified in UTUC and normal plasma samples of UTUC discovery cohort. Boxplots show median (central line), upper and lower quartiles (box limits), 1.5× interquartile range (whiskers).

(F) Dynamic range of the protein identification of each sample according to the descending sort of protein abundance in UTUC and normal plasma samples of UTUC discovery cohort.

(G) Components identified in plasma proteome.

(H) Cancer-related proteins and proteins associated with drugs approved by the FDA identified in UTUC discovery cohort.