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. 2023 Aug 25;4(9):101166. doi: 10.1016/j.xcrm.2023.101166

Figure 5.

Figure 5

Plasma proteomic profiles identify patients with muscle-invasive UTUC

(A) Kaplan-Meier curves for OS and PFS of NMI-UTUCs versus MI-UTUCs.

(B) Bar plot for T category in NMI-UTUCs and MI-UTUCs.

(C) Difference in protein abundance between NMI-UTUCs and MI-UTUCs.

(D) Pathways enriched for DEPs in NMI-UTUCs and MI-UTUCs.

(E) Fold changes of DEPs from comparison of NMI-UTUCs and MI-UTUCs in UTUC and normal plasma samples.

(F) Strategy for screen diagnosis plasma signature proteins.

(G) Protein abundance of TST and HPCAL1 among normal, NMI-UTUCs, and MI-UTUCs in tissue (top) and plasma (bottom) cohorts. Boxplots show median (central line), upper and lower quartiles (box limits), 1.5× interquartile range (whiskers).

(H) RNA expression level of TST and HPCAL1 in NMI-UTUC and MI-UTUC tissues in WCM UTUC cohort.

(I) ROC curves of classifier model in predicting NMI-UTUCs and MI-UTUCs in 70% training and 30% test set.