Figure 6.

Clinical features associated with proteomic profiles

(A) Pairwise Spearman correlation of proteins and clinical variables for UTUC plasma discovery cohort, resulting in matrix of correlation coefficients where each variable is compared to all others. Main clusters are functionally annotated with keywords.

(B) Magnified area highlights fibrinogen (FIB) (red) and 16 proteins, quantified using plasma proteome profiling (black).

(C) Volcano plot shows correlation between plasma FIB and protein abundance.

(D) Pathways enriched for proteins significantly positively or negatively correlated with FIB.

(E) Heatmap of plasma FIB level and protein abundance significantly positively correlated with FIB.

(F) (Left) Heatmap of lymph node involvement (LNI) score and abundance of 14 proteins highly positively associated with LNI. (Right) The prognostic risk scores (hazard ratios) of each protein.