Table 1.

Serum biomarkers in mice treated with vehicle, Lira, BemA, or Lira+BemA

	Group (mean ± SEM)
	Vehicle		Lira		Lira+BemA		Control	BemA
Measure	n = 8	p value	n = 9	p value	n = 9	p value	n = 9	n = 9	p value
ALT (U/mL)	230.4 ± 31.1	0.4017	337.5 ± 90.1	0.5967	356.2 ± 85.5	0.4936	280 ± 46.5	33.5 ± 19.4	0.0002
AST (U/mL)	63.3 ± 7.3	0.0598	128.4 ± 30.6	0.1891	144.1 ± 28.5	0.0846	92.7 ± 11.9	28.4 ± 4.3	0.0001
SAA (ng/mL)	2743 ± 60	0.8786	1,092 ± 248	0.0004	1,154 ± 331	0.0005	2,730 ± 49	1,064 ± 176	<0.0001
CXCL10 (pg/mL)	11.6 ± 1.4	0.6811	10 ± 0.6	0.4470	8.4 ± 0.9	0.0689	12.7 ± 1.9	7.3 ± 0.5	<0.0001
CRP (pg/mL)	29,169 ± 5,539	0.7668	18,033 ± 2,133	0.0634	12,227 ± 983	0.0038	31,873 ± 6,845	15,664 ± 3,074	0.0463
sPLA2 (nmol/min/mL)	26.9 ± 1.1	0.6052	20.5 ± 0.5	0.0003	16.3 ± 1.1	<0.0001a	28 ± 1.7	19.3 ± 0.8	0.0003

p values reported are based on comparisons used throughout the remainder of manuscript—unpaired t test between control and BemA and one-way ANOVA with Tukey post hoc between vehicle, Lira, and Lira+BemA. Significance was accepted at p <0.05. n = 8–9 mice/group. ALT, alanine transaminase; AST, aspartate aminotransferase; SAA, serum amyloid A; CXCL10, C-X-C motif chemokine ligand 10, also known as interferon gamma-induced protein 10 (IP-10); CRP, C-reactive protein; sPLA2, secretory phospholipase A2.

^aSignificant difference p <0.05 between Lira and Lira+BemA.