Table 2.
Endocrine and glycemic characteristics of children with LEP, LEPR, and MC4R mutations and lean controls
| Characteristic | LEP deficient | LEPR deficient | MC4R deficient | Controls |
|---|---|---|---|---|
| Leptin, ng/mL (n) | 0.1 ± 0.0a,b (108) | 31.9 ± 2.7c,d (49) | 26.7 ± 3.5c,d (26) | 3.1 ± 0.1a,b (68) |
| Insulin, μIU/mL (n) | 24.6 ± 2.3a,b,d (111) | 41.8 ± 5.9c,d (49) | 49.0 ± 10.3c,d (26) | 6.9 ± 0.5a,b,c (61) |
| Cortisol, μg/dL (n) | 16.2 ± 0.8a,b,d (111) | 13.3 ± 0.7c,d (49) | 10.9 ± 0.8c (26) | 9.4 ± 0.3a,c (61) |
| TSH, μIU/mL (n) | 2.2 ± 0.1 (112) | 2.3 ± 0.2 (49) | 2.1 ± 0.2 (26) | 2.2 ± 0.1 (61) |
| HbA1C (n) | 5.2 ± 0.1d (29) | 5.0 ± 0.1b,d (19) | 5.9 ± 0.5a,d (7) | 4.2 ± 0.1a,b,c (40) |
| RBG∗, mg/dL (n) | 95.7 ± 3.2 (30) | 99.7 ± 3.7 (23) | 109.1 ± 7.8 (15) | 102.8 ± 2.6 (40) |
| T4, μg/dL (n) | 8.4 ± 0.6 (23) | 7.0 ± 0.5 (11) | 7.6 ± 0.9 (15) | 8.1 ± 0.3 (27) |
| T3, ng/mL (n) | 1.8 ± 0.1 (23) | 1.9 ± 0.2 (11) | 1.6 ± 0.1 (15) | 1.5 ± 0.1 (27) |
Data represent mean ± SEM.
∗Random blood glucose
a
Statistically significant p <0.05 (Scheffe’s multiple test) vs. LEPR deficient.
b
Statistically significant p <0.05 (Scheffe’s multiple test) vs. MC4R deficient.
c
Statistically significant p <0.05 (Scheffe’s multiple test) vs. LEP deficient.
d
Statistically significant p <0.05 (Scheffe’s multiple test) vs. controls.