Figure 2.

A delay in viral rebound was not detected after 3 weeks of S63845 treatment

(A) Schematic timeline depicting HIV-1 infection, suppressive ART period, and the dosing regimen of S63845 (blue arrows; twice weekly).

(B) Plasma viral loads of individual hu-mice over the course of the experiment (n = 8 mice per group). LOD is indicated with a dotted horizontal line (2.3 log₁₀ RNA copies mL⁻¹).

(C) Kaplan-Maier curve representing the time to viral rebound following ART interruption.

(D) Peripheral CD4⁺ T cell counts over the course of the experiment.

p value for Kaplan-Maier curve (C) was calculated using a log-rank Mantel-Cox test. p value for each time point in (D) was analyzed using an unpaired t test corrected for multiple comparisons with the Holm-Šìdák method.