Figure 3.

Viral rebound was delayed after a 3 week combined course of venetoclax and S63845

(A) Schematic timeline depicting HIV-1 infection, suppressive ART, and the dosing regimen of venetoclax (red arrows; administered every weekday) and S63845 (blue arrows; twice weekly).

(B) Plasma viral loads of individual hu-mice over the course of the experiment (n = 4–7 mice per group). LOD is indicated with a dotted horizontal line (2.3 log₁₀ RNA copies mL⁻¹).

(C) Kaplan-Maier curve representing the time to viral rebound following ART interruption.

(D) Peripheral CD4⁺ T cell counts over the course of the experiment.

p value for Kaplan-Maier curve (C) was calculated using a log-rank Mantel-Cox test. p value for each time point in (D) was analyzed using an unpaired t test corrected for multiple comparisons with the Holm-Šìdák method. “845” = S63845.