Table 4.
Laboratory characteristics of G6PD deficient subjects and matched controls.
| G6PD Deficiency (median [IQR]) |
Control (median [IQR]) |
p | SMD | |
|---|---|---|---|---|
| Blood Count | ||||
| Red Blood Cells (M/uL) | 4.59 [4.26-4.92] | 4.83 [4.50-5.16] | <0.001 | -0.419 |
| Hemoglobin (g/dL) | 13.00 [11.90-14.30] | 13.40 [12.20-14.70] | <0.001 | -0.225 |
| Hematocrit (%) | 38.80 [35.70-42.50] | 39.60 [36.40-43.30] | <0.001 | -0.165 |
| White Blood Cells (K/uL) | 7.01 [5.75-8.85] | 7.25 [5.94-9.07] | <0.001 | -0.068 |
| Neutrophils (K/uL) | 3.41 [2.61-4.47] | 3.51 [2.68-4.60] | <0.001 | -0.058 |
| Neutrophils (%) | 51.70 [42.20-59.40] | 51.20 [42.00-59.00] | 0.15 | 0.011 |
| Lymphocytes (K/uL) | 2.40 [1.87-3.23] | 2.47 [1.92-3.32] | <0.001 | -0.047 |
| Lymphocytes (%) | 36.0 [29.0-44.5] | 36.2 [29.0-44.5] | 0.82 | 0.006 |
| Eosinophils (K/uL) | 0.19 [0.11-0.32] | 0.19 [0.12-0.33] | 0.002 | -0.035 |
| Eosinophils (%) | 2.70 [1.70-4.40] | 2.70 [1.70-4.50] | 0.560 | -0.008 |
| Basophils (K/uL) | 0.04 [0.03-0.06] | 0.04 [0.03-0.06] | 0.742 | -0.007 |
| Basophils (%) | 0.60 [0.40-0.80] | 0.60 [0.40-0.80] | <0.001 | 0.053 |
| Monocytes (K/uL) | 0.54 [0.43-0.69] | 0.58 [0.46-0.73] | <0.001 | -0.141 |
| Monocytes (%) | 7.80 [6.60-9.20] | 8.00 [6.80-9.50] | <0.001 | -0.096 |
| Platelets (K/uL) | 265 [219-321] | 260 [214-318] | <0.001 | 0.059 |
| Mean Platelet Volume (fL) | 10.80 [10.20-11.60] | 10.80 [10.10-11.50] | <0.001 | 0.052 |
| Biochemistry | ||||
| Fasting glucose (mg/dL) | 89.00 [83.4-96.0] | 89.6 [83.8-97.1] | <0.001 | -0.041 |
| Creatinine (mg/dL) | 0.70 [0.52-0.85] | 0.71 [0.54-0.87] | <0.001 | -0.050 |
| Creatine Kinase (U/L) | 87.0 [60.0-127.0] | 95.0 [66.0-138.0] | <0.001 | -0.036 |
| Urea (mg/dL) | 27.2 [22.3-33.0] | 27.2 [22.2-33.2] | 0.52 | 0.005 |
| Uric Acid (mg/dL) | 4.93 [3.95-5.98] | 5.06 [4.04-6.11] | <0.001 | -0.082 |
| Iron (ug/dL) | 94.0 [66.4-125.7] | 80.4 [58.5-105.8] | <0.001 | 0.369 |
| Ferritin (ng/mL) | 69.0 [33.8-144.3] | 48.0 [23.5-100.7] | <0.001 | 0.282 |
| Tranferrin (mg/dL) | 258 [233-288] | 266 [240-295] | <0.001 | -0.149 |
| Tranferrin Saturation (%) | 26.2 [18.0-35.7] | 21.9 [15.6-29.0] | <0.001 | 0.401 |
| Bilirubin, Total (mg/dL) | 0.76 [0.55-1.09] | 0.56 [0.42-0.78] | <0.001 | 0.225 |
| Total Protein (g/dL) | 7.18 [6.89-7.47] | 7.11 [6.81-7.41] | <0.001 | 0.148 |
| Globulin (g/dL) | 2.86 [2.60-3.12] | 2.80 [2.56-3.06] | <0.001 | 0.129 |
| Immunoglobulins | ||||
| Immunoglobulin A (mg/dL) | 186 [112-267.5] | 159 [97-229] | <0.001 | 0.256 |
| Immunoglobulin G (mg/dL) | 1135 [945.5-1323] | 1049 [883-1230] | <0.001 | 0.252 |
| Immunoglobulin M (mg/dL) | 99 [70-141] | 96 [68-135] | 0.07 | 0.049 |
| Inflammatory Markers | (mean ± sth. dev.) | (mean ± sth. dev.) | ||
| Erythrocyte sedimentation rate (mm/hr) | 20.69 ± 19.82 | 18.98 ± 18.14 | <0.001 | 0.093 |
| C-reactive protein (mg/L) | 7.72 ± 19.69 | 7.86 ± 20.58 | 0.15 | -0.007 |
| C3 Complement (mg/dL) | 128.38 ± 24.55 | 130.44 ± 23.71 | 0.04 | -0.086 |
| C4 Complement (mg/dL) | 31.71 ± 10.46 | 33.52 ± 10.63 | <0.001 | -0.170 |
IQR, Interquartile range; SMD, Standardized Mean Difference.