REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal anti-p-AKT (S473)	Cell Signaling Technology	Cat# 4060; RRID: AB_2315049
Rabbit monoclonal anti-AKT	Cell Signaling Technology	Cat# 4691; RRID: AB_915783
Mouse monoclonal anti-β-actin	Santa Cruz Biotechnology	Cat# sc-47778; RRID: AB_626632
Mouse monoclonal anti-β-tubulin	Abmart	Cat# M20005; RRID: AB_2920648
HRP-labeled goat anti-rabbit secondary antibody	MultiSciences	Cat# GAR007; RRID: AB_2827833
HRP-labeled goat anti-mouse secondary antibody	MultiSciences	Cat# GAM007; RRID: AB_2927718
Rabbit monoclonal anti-HPL	Abmart	N/A
Chemicals, peptides, and recombinant proteins
TRIzol™	Invitrogen	Cat# 15596018
RIPA Lysis Buffer	Beyotime	Cat# P0013B
Potassium sodium tartrate	HUSHI	Cat# 10017818; CAS: 6381-59-5
3,5-Dinitrosalicylic acid	HUSHI	Cat# 30073424; CAS: 609-99-4
Sodium hydroxide	HUSHI	Cat# 10019762; CAS: 1310-73-2
Phenol	HUSHI	Cat# 40040761; CAS: 108-95-2
Bovine insulin	Yuanye	Cat# S12033; CAS: 11070-73-8
Trehalose	Macklin	Cat# D807342; CAS: 99-20-7
LY294002	Beyotime	Cat# S1737; CAS: 154447-36-6
Critical commercial assays
PrimeScript™ RT reagent Kit (Perfect Real Time)	TaKaRa	Cat# RR037B
Glycogen assay kit	COMIN	Cat# TY-1-Y
BCA protein assay kit	Beyotime	Cat# P0012
Deposited data
Raw RNA-seq data	This paper	GEO: GSE242203
Experimental models: Organisms/strains
Female Silkworm (Bombyx mori)	School of Biology and Basic Medical Sciences, Suzhou Medical College, Soochow University	N/A
Oligonucleotides
See Table S1 for the Primers used in qRT-PCR	This paper	N/A
Software and algorithms
GraphPad Prism 8	La Jolla, CA, USA	https://www.graphpad.com/
ImageJ	National Institutes of Health	https://imagej.nih.gov/ij/