Fig. 4.

Signature-based model demonstrates high accuracy and robust perfor-mance in predicting prognosis. (a)C-index of 101 kinds of prediction models in TCGA-KIRC and E-MTAB-1980 datasets. (b)The importance of the 17 most valuable signature genes based on the RSF algorithm. (c)KM survival curves with log-rank test demonstrate survival discrepancies between high- and low-score groups of TCGA-KIRC (up) and E-MTAB-1980 (bottom) datasets. (d) The model is an independent risk factor for OS in TCGA-KIRC (left) and E-MTAB-1980 (right) datasets by multivariate cox re-gression analysis. (e) Time-dependent ROC analysis demonstrates the performance of the model in TCGA-KIRC (left) and E-MTAB-1980 (right) datasets at 1y-, 3y-, and 5y- time points.