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. 2023 Sep 14;29(34):5054–5074. doi: 10.3748/wjg.v29.i34.5054

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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

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Differential expression of mRNAs and microRNAs between the treatment and model groups. A: The volcano plot of differentially expressed mRNAs between the treatment and model groups. The upper left quadrant and the upper right quadrant in the figure represent downregulated and upregulated mRNAs, respectively; B: The volcano plot of differentially expressed microRNAs (miRNAs) between the treatment and model groups. The upper left quadrant and the upper right quadrant in the figure represent downregulated and upregulated miRNAs, respectively; C: Heatmap shows the 50 mRNAs that exhibited the highest upregulation and downregulation in the treatment group relative to the model group; D: Heatmap shows the miRNAs that exhibited the highest upregulation and downregulation in the treatment group relative to the model group.