Figure 2.

Examples of discrepant cases from Herlev cohort used in [22]; purple areas: tumor nests, heatmap areas: sTIL regions. (A) A case of high sTIL density at tumor margin compared to central area. As the stroma is scarce inside the tumor, sTIL density is reported to be very high in CTA as mostly the margin contributes to the score. (B) The tumor grows irregularly with small tumor nests between larger invasive tumor areas. In these cases, the CTA includes more stroma than VTA, resulting in a lower sTIL density score (larger denominator) than the manual score.