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. Author manuscript; available in PMC: 2023 Sep 25.

Published in final edited form as: Toxicol Appl Pharmacol. 2022 Feb 15;440:115922. doi: 10.1016/j.taap.2022.115922

Figure 4: — Simulated external concentrations (mg/kg bw/day) versus area under the curve of plasma concentrations during the last 24 hours (AUC; in μmole*h/L) of the parent and the metabolite, assuming saturable or first-order metabolism for hypothetical chemicals A (panel A) and B (panel B); saturable or first-order urinary excretion for hypothetical chemicals A (panel C) and B (panel D); or saturable or first-order urinary excretion of the metabolites for hypothetical chemicals A (panel E) and B (panel F).

Figure 4: — Simulated external concentrations (mg/kg bw/day) versus area under the curve of plasma concentrations during the last 24 hours (AUC; in μmole*h/L) of the parent and the metabolite, assuming saturable or first-order metabolism for hypothetical chemicals A (panel A) and B (panel B); saturable or first-order urinary excretion for hypothetical chemicals A (panel C) and B (panel D); or saturable or first-order urinary excretion of the metabolites for hypothetical chemicals A (panel E) and B (panel F).