Table 2.

Docking scores of luteolin (3,4,5,7-tetrahydroxyflavone) (LUT) bound to 6 crucial target proteins and 3 common clinical targets.

Proteins	Compound	Glide gscore	Glide hbond	Glide evdw	Glide ecoul	Glide energy
ALB (1HK4)	Contrast	−6.123	−0.442	−36.688	−9.173	−45.862
	Luteolin	−7.285	−0.289	−31.373	−9.605	−40.978
AKT1 (3CQU)	Contrast	−9.465	−0.608	−46.455	−7.047	−53.503
	Luteolin	−8.122	0	−34.412	−11.862	−46.274
CASP3 (1NMS)	Contrast	−5.558	−0.674	−32.781	−6.181	−38.962
	Luteolin	−5.85	−0.152	−23.962	−13.848	−37.81
EGFR (3POZ)	Contrast	−10.391	−0.318	−59.946	−6.215	−66.161
	Luteolin	−8.526	−0.320	−24.478	−18.665	−43.143
HSP90AA1 (2YI7)	Contrast	−7.609	−0.172	−41.046	−10.810	−51.856
	Luteolin	−7.161	−0.320	−35.367	−7.523	−42.890
MAPK1 (1PME)	Contrast	−7.914	−0.370	−37.564	−9.106	−46.669
	Luteolin	−9.015	−0.320	−46.420	−5.544	−51.964
ACE2 (1R4L)	Contrast	−8.602	−0.874	−39.865	−17.627	−57.492
	Luteolin	−6.328	−0.144	−32.543	−14.439	−46.982
Main protease (5R82)	Contrast	−5.559	−0.32	−20.16	−5.642	−25.802
	Luteolin	−6.045	−0.289	−18.973	-−17.841	−36.813
3CL protease (6M2N)	Contrast	−7.732	−0.391	−34.23	−17.627	−43.793
	Luteolin	−8.020	−0.596	−38.311	−14.439	−45.522

Glide hbond refers to hydrogen bonding. Glide evdw refers to Van der Waals interactions. Glide ecoul refers to Coulomb energy. All items are components of the Glide gscore algorithm.

ACE2 = angiotensin I converting enzyme 2, AKT1 = RAC-alpha serine/threonine-protein kinase, ALB = albumin, CASP3 = caspase-3, EGFR = epidermal growth factor receptor, HSP90AA1 = heat shock protein HSP 90-alpha, MAPK1 = mitogen-activated protein kinase 1.