TABLE 2.
The 5-year cumulative incidence of liver-related events and death stratified based on FIB-4, FAST score, and liver-stiffness measurement
| FIB-4 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| <1.3 | 1.3–2.67 | >2.67 | All patients | ||||||
| Liver-related events | 5-y cumulative incidence (n = 749) (%) |
Incidence rate per 1000 person-years | 5-y cumulative incidence (n – 398) (%) |
Incidence rate per 1000 person-years | 5-y cumulative incidence (n = 115) (%) |
Incidence rate per 1000 person-years | p a | 5-y cumulative incidence (%) | Incidence rate per 1000 person-years |
| LSM (kPa) | |||||||||
| <8 | 0 | 0 (0.0–0.2) | 0 | 0.00 (0.00–5.89) | 14.3 (0.5–49.1) | 14.03 (0.36–78.17) | <0.001 | 0.5 (0.0–2.4) | 0.42 (0.01–2.33) |
| 8–12 | 0 | 0(0.0–0.8) | 0 | 0.00 (0.00–11.57) | 0 | 0.00 (0.00–45.45) | NA | 0 | 0.00 (0.00–4.53) |
| >12 | 0 | 0 (0.0–1.4) | 15.6 (3.0–37.5) | 13.78 (3.75–35.28) | 29.2 (15.2–44.6) | 64.48 (34.33–110.26) | < 0.001 | 14.7 (7.5–24.2) | 23.30 (13.57–37.31) |
| p | NA | 0.0017 | 0.019 | — | <0.001 | ||||
| All patients | 0 | 0.00 (0.00–1.57) | 3.9 (0.9–10.9) | 3.24 (0.88–8.29) | 20.3 (10.6–32.0) | 39.54 (21.62–66.34) | <0.001 | 3.3 (1.7–5.8) | 4.58 (2.71–7.24) |
| FAST score | |||||||||
| <0.35 | 0 | 0 (0.0–0.3) | 13.8 (1.3–40.4) | 5.33 (0.65–19.26) | 14.3 (0.5–49.1) | 21.14 (0.54–117.81) | <0.001 | 3.6 (0.8–10.5) | 1.89 (0.39–5.53) |
| 0.35–0.67 | 0 | 0 (0.0–0.4) | 0 | 0.00 (0.00–7.00) | 19.6 (2.4–49.1) | 31.59 (6.51–92.32) | < 0.001 | 1.1 (0.2–3.3) | 1.91 (0.39–5.58) |
| >0.67 | 0 | 0 (0.0–1.5) | 2.6 (0.5–8.4) | 6.00 (0.73–21.68) | 21.2 (9.9–35.4) | 47.21 (22.64–86.83) | <0.001 | 7.6 (3.9–12.9) | 15.50 (8.01–27.08) |
| p | NA | 0.20 | 0.65 | < 0.001 | |||||
| All patients | 0 | 0.00 (0.00–1.57) | 3.9 (0.9–10.9) | 3.24 (0.88–8.29) | 20.3 (10.6–32.0) | 39.54 (21.62–66.34) | <0.001 | 3.3 (1.7%–5.8%) | 4.58 (2.71–7.24) |
| Liver-related events or death | |||||||||
| LSM (kPa) | |||||||||
| <8 | 0 | 0 (0.0–0.2) | 1.4 (0.3–4.5) | 3.20 (0.39–11.54) | 14.3 (0.5–49.1) | 14.03 (0.36–78.17) | 0.0016 | 0.8 (0.2–2.5) | 1.26 (0.26–3.67) |
| 8–12 | 0 | 0 (0.0–0.8) | 0 | 0.00 (0.00–11.57) | 8.0 (1.3–22.9%) | 24.64 (2.98–89.01) | <0.001 | 0.8 (0.2–2.7%) | 2.46 (0.30–8.87) |
| >12 | 0 | 0 (0.0–0.01) | 15.6 (3.0–37.5) | 13.78 (3.75–35.28) | 29.2 (15.2–44.6) | 64.48 (34.33–110.26) | <0.001 | 14.7 (7.5–24.2) | 23.30 (13.57–37.31) |
| pb | — | — | 0.037 | 0.14 | — | <0.001 | <0.001 | ||
| All patients | 0 | 0 (0.00–1.57) | 4.6 (1.3–11.3) | 4.86 (1.78–10.57) | 22.1 (12.1–33.8) | 45.19 (25.83–73.38) | <0.001 | 3.7 (2.0–6.1) | 5.60 (3.51–8.47) |
| FAST | |||||||||
| <0.35 | 0 | 0 (0.0–0.3) | 16.0 (2.2– 1.5) | 10.66 (2.90–27.30) | 14.3 (0.5–49.1) | 21.14 (0.54–117.81) | 0.001 | 4.2 (1.1–10.8) | 3.15 (1.02–7.36) |
| 0.35–0.67 | 0 | 0 (0.0–0.4) | 0 | 0 (0.00–7.00) | 22.6 (3.7–51.3) | 42.12 (11.48–107.84) | < 0.001 | 1.3 (0.4–3.5) | 2.55 (0.69–6.52) |
| >0.67 | 0 | 0 (0.0–1.4) | 2.6 (0.5–8.4) | 6.00 (0.73–21.68) | 22.8 (11.1–37.0) | 51.94 (25.93–92.93) | < 0.001 | 8.0 (4.2–13.4) | 16.80 (8.94–28.72) |
| p | NA | 0.056 | 0.62 | — | <0.001 | ||||
| All patients | 0 | 0 (0.0–0.1) | 4.6 (1.3–11.3) | 4.86 (1.78–10.57) | 22.1 (12.1–33.8) | 45.19 (25.83–73.38) | < 0.001 | 0.7 (2.0–6.1) | 5.60 (3.51–8.47) |
Note: Incidence rate is shown as events in 1000 per person-years (95% CI) in the overall cohort. Person-years was rounded to the nearest.
a
p-value reflects differences between cumulative incidence between different subgroups of FIB-4, LSM, and/or FAST using Fisher-exact test. 5-year cumulative incidence is shown as events/number at risk (%, 95% CI).
Abbreviations: FAST, Fibroscan-AST; FIB-4, Fibrosis index 4; LRE, liver-related events; LSM, liver-stiffness measurement.