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. Author manuscript; available in PMC: 2023 Sep 25.
Published in final edited form as: Curr Biol. 2022 Jul 20;32(17):3690–3703.e5. doi: 10.1016/j.cub.2022.06.089

Figure 1. Food insecurity feeding paradigm, experimental timeline, and mouse weight gain.

Figure 1.

A, Mice were assigned to 2 different groups, Ad lib (AL) and Food Insecurity (FI) at P21. After P41, both AL and FI mice were fed ad libitum until testing. Behavioral or neurobiological testing were performed after P60. B, Schematic illustrates the P21-P40 treatment differences. AL mice had free access to food daily while FI mice received food in alternating ‘feast and famine’ days. C, Food was delivered to the FI mice with variable ratio (with a 5.0g total baseline delivered every 48 hours). D, FI mice showed transient disruption of weight gain during the P21-40 (n(AL)=30, n(FI)=25). E, Male mice weight (n(AL)=16, n(FI)=12) showed no group differences in weight gain in adulthood. Note, all mice underwent food restriction for 4COF task in the P60s. F, Female mice (n(AL)=14, n(FI)=13) showed significant differences in weight gain in adulthood. **p<0.01, ***p<0.001, ****p<0.0001. D-F, Data are represented as mean ± SEM. See also Figure S1.