TABLE 2.
Results of the reduced additive‐effects models for total ADHD symptoms in the European‐ancestry subgroups of the ABCD and Oregon‐ADHD‐1000 cohorts.
| Cohort/risk factor | Effect estimate | p‐value | R 2 |
|---|---|---|---|
| ABCD—White/European | |||
| ADI | 0.063 (0.024, 0.102) | .001 | .028 |
| Family income | −0.096 (−0.129, −0.062) | 2.76e‐8 | .038 |
| Family conflict | 0.201 (0.172, 0.231) | <2e‐16 | .066 |
| ADHD‐PRS | 0.098 (0.071, 0.125) | 2.15e‐12 | .037 |
| Total R 2 | .091 | ||
| ABCD matched—White/European | |||
| Family income | −0.125 (−0.204, −0.047) | .002 | .046 |
| Family conflict | 0.263 (0.190, 0.337) | 5.34e‐12 | .091 |
| ADHD‐PRS | 0.195 (0.121, 0.268) | 2.68e‐7 | .060 |
| Total R 2 | .145 | ||
| Oregon‐ADHD‐1000—White/European | |||
| Negative sentiment | 0.331 (0.259, 0.403) | <2e‐16 | .137 |
| ADHD‐PRS | 0.192 (0.120, 0.263) | 2.09e‐7 | .071 |
| Total R 2 | .173 | ||
Note: The effect estimates (standardized regression coefficients) and p‐values are those from the additive model containing all risk factors listed for each cohort. R 2 values are reported for each individual risk factor (from the main effects models; italicized) as well as for the reduced additive model shown (Total R 2).
Abbreviations: ABCD, Adolescent Brain Cognitive Development Study; ADHD‐PRS, attention‐deficit/hyperactivity disorder‐polygenic risk score.