Table 1.

Preclinical evidence that the enantiomer (S)-ketamine, but not (R)-ketamine, has similar sleep-wake effects to (R,S)-ketamine

Reference	Drugs	Dose and route of administration	Species	Time spent in wakefulness	Time spent in NREM sleep	Time spent in REM sleep	REM sleep latency time
Banerjee et al., 2020	(R,S)-ketamine	30 mg/kg i.p.	Wistar rat	↑	↓	↓	↑
This study	(S)-ketamine	15 mg/kg i.p.	Wistar rat	↑	↓	↓	↑
This study	(R)-ketamine	15 mg/kg i.p.	Wistar rat	ø	ø	ø	ø

Abbreviations: ↑, increased, ↓, decreased, ø, no effect.