Table 3.
Changes in hemodynamics and vitals following catheter-directed mechanical thrombectomy
| Initial Mean ± SD |
After CDMT Mean ± SD |
Mean Change Mean ± SD (%) |
P value | |
|---|---|---|---|---|
| RV/LV ratio (CTPA) | 1.4 ± 0.3 | 0.94 ± 0.1 | −0.48 ± 0.4 (36) | <0.0001 |
| RV/LV ratio (TTE) | 1.3 ± 0.3 | 0.97 ± 0.1 | −0.33 ± 0.1 (42.9) | <0.0001 |
| Composite RV/LV (CTPA/TTE) a | 1.4 ± 0.3 | 0.94 ± 0.1 | −0.46 ± 0.1 (32.9) | <0.0001 |
| sPAP, mmHg | 52.9 ± 16.0 | 44 ± 13.4 | −10.4 ± 7.8 (19.7) | <0.0001 |
| mPAP, mmHg | 32.5 ± 7 | 25.1 ± 8.5 | −6.1 ± 4.2 (18.8) | <0.0001 |
| dPAP, mmHg | 21.1 ± 5.7 | 16.8 ± 8.5 | −5.9 ± 6.1 (28.0) | <0.0001 |
| mRAP, mmHg | 14.1 ± 2.9 | 11.2 ± 2.4 | −3.9 ± 3.5 (27.7) | <0.0001 |
| PAPI, mmHg/mmHg | 4.2 ± 2.2 | 7.6 ± 6.6 | +3.0 ± 5.6 (71.4) | <0.0001 |
| CO | 4.8 ± 1.3 | 5.0 ± 1.2 | +0.2 ± 0.1 (4.2) | 0.0008 |
| TPVR, WU | 4.5 ± 2.4 | 3.3 ± 1.8 | −1.2± 0.9 (26.7) | 0.003 |
| TAPSE, mm | 15 ± 4.1 | 20.5 ± 4.6 | +6.1 ± 4.5 (40.7) | <0.0001 |
| Heart rate, bpm | 110.7 ± 16.8 | 89.5 ± 13.8 | −23.9 ± 15.3 (21.6) | <0.0001 |
| SBP, mmHg | 115.1 ± 22.3 | 122.3 ± 13.9 | +8.7 ± 20.9 (7.6) | 0.07 |
| DBP, mmHg | 74.9 ± 15.8 | 79 ± 10.6 | +5.4 ± 15.0 (7.2) | 0.15 |
| Arterial pO2, mmHg | 66.9 ± 5.5 | 76.9 ± 2.8 | +13.1 ± 17.2 (19.6) | 0.0009 |
| FiO2 | 0.6 ± 0.3 | 0.43 ± 0.1 | − 0.27 ± 0.2 (45.0) | <0.0001 |
| hs Troponin I, ng/mL | 2.4 ± 0.7 | 2.1 ± 1.2 | −1.6 ± 7.6 (66.7) | <0.0001 |
| NT-proBNP, pg/mL | 5609.7 ± 5805.3 | 3319.7 ± 415.9 | − 3277.4 ± 1667.1 (58.4) | <0.0001 |
| Lactate, mmol/L | 2.8 ± 0.2 | 1.9 ± 0.1 | −0.9 ± 2.4 (32.1) | <0.0001 |
| Haemoglobin concentration, mmol/L | 8.3 ± 0.1 | 7.7 ± 0.2 | −0.8 ± 1.5 (9.6) | <0.0001 |
Composite RV/LV ratios using either CTPA or TTE measurements, with CTPA prioritized if both were available.
Abbreviations: See Table 1. CO, cardiac output; DBP, diastolic blood pressure; dPAP, diastolic pulmonary arterial pressure; mPAP, mean pulmonary arterial pressure; mRAP, mean atrial pressure; PAPI, pulmonary artery pulsatility index; SBP, systolic blood pressure; sPAP, systolic pulmonary pressure; TPVR, total pulmonary vascular resistance; WU, Wood Units.