Skip to main content
. 2023 Sep 25;14:5977. doi: 10.1038/s41467-023-41534-w

Fig. 6. The protective role of ALR Myo9b KI is independent of its direct effect on T cells.

Fig. 6

a Schematic outline of the experimental design and time line of adoptive transfer model. b The incidence of diabetes in ALR Myo9b KI NOD-scid (n = 7) and NOD-scid (n = 11) mice after adoptive transfer of BDC2.5 naive CD4+ T cells. c Representative results showing H&E staining of pancreases from KI-scid and NOD-scid mice 12 days after transfer. Scale bars: 50 μm. Original magnification: ×400. (d–g) Representative FACS plots and frequencies of CD4+ T cells (d), Th1 (e), Th17 (f), and Treg (g) subpopulations in the PLNs and spleen are shown. n = 4 per group (c–g). Data are presented as mean ± SEM. Statistical difference in b was analyzed by log-rank test; data from other figure parts were analyzed by unpaired two-sided Student’s t test.