Fig. 9. Identification and characterization of the rare variant rs764932023 in MYO9B.

a Flow diagram for study design and data analysis. b Schematic representation of the approximate locations of variants Rs764932023, Rs766200985, and Rs776331004 relative to the MYO9B gene. c Genotyping result for Rs764932023 in T1D cases and healthy controls. d Alignment of MYO9B sequences in different species. The conserved Arg133 is framed in red. e MYO9B expression in MoDCs from healthy controls carrying variant Rs764932023 and those without the variant. n = 4 for each genotype. Values are expressed as mean ± SEM. Statistical difference in c was assessed using Fisher’s exact test; in e was determined by unpaired two-sided Student’s t test.