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. 2023 Sep 25;13:16010. doi: 10.1038/s41598-023-42550-y

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Photomicrographs of H&E-stained aorta sections. (a) Aorta of control rat showing normal histological structure of the aortic three layers; intima (arrow), media (M) and adventitia (A). (b–d) Aorta of obese rat showing splitting of the medial muscles (M) with congested vessels, free RBCs, mononuclear inflammatory cells, atherosclerotic plaque, and many lipophages (insert and arrow). Aortae of (e) low and (f) high doses ZnONPs administrated rats showing significant improvement in the histological changes with absence of any plaque as well as lipophages. (g, h) Marked reduction in the aortic tunica thickening. Each bar represents the mean ± SE of 8 rats. *vs normal control group, ^@vs obese group, ^#vs ZnONPs (5 mg/kg) at p < 0.05. ZnONPs: Zinc oxide nanoparticle.