Table 2.
Plasma lipid profile (mg/dl), adipocyte hormones (µg/L), nitric oxide (µmol/ml) levels and blood pressure (mmHg) of obese rats treated with zinc oxide nanoparticles.
| Treatment Parameter | Control | Obese | O + ZnONPs 5 mg/kg |
O + ZnONPs 10 mg/kg |
|---|---|---|---|---|
| Cholesterol | 95.16 ± 2.95 | 211.5 ± 4.724* | 134.1 ± 2.962*@ | 89.75 ± 7.034@# |
| Triglycerides | 70.22 ± 1.78 | 244 ± 14.58* | 204.5 ± 15.47* | 173.7 ± 13.75*@ |
| HDL | 39.07 ± 2.44 | 7.55 ± 0.4734* | 29.22 ± 2.45*@ | 41.6 ± 2.576@# |
| LDL | 22.76 ± 1.36 | 92.51 ± 1.68* | 44.94 ± 2.362*@ | 26.26 ± 0.9407@# |
| Atherogenic index | 0.26 ± 0.03 | 1.51 ± 0.0416* | 0.8492 ± 0.0583*@ | 0.6175 ± 0.0394*@# |
| Leptin | 1.87 ± 0.15 | 3.11 ± 0.15* | 2.19 ± 0.25*@ | 1.94 ± 0.19@# |
| Adiponectin | 196 ± 10.31 | 51.13 ± 1.49* | 151.88 ± 8.33*@ | 188.13 ± 8.80@# |
| Nitric oxide | 40.80 ± 1.16 | 17.88 ± 0.78* | 26.00 ± 1.05* | 38.50 ± 1.68@# |
| Systolic BP | 117.87 ± 2.13 | 145.76 ± 2.95* | 130.38 ± 1.06*@ | 121.62 ± 1.89 @ |
| Diastolic BP | 81.13 ± 1.62 | 102.50 ± 2.60* | 88.38 ± 1.44@ | 80.75 ± 2.23@ |
Each value represents the mean of 8 animals ± SE. Statistical analysis was performed using one-way ANOVA followed by Tukey–Kramer multiple comparisons test (*vs control group, @vs obese group and #vs ZnONPs 5 mg/kg) at p < 0.05. O: Obese.