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. 2023 Sep 25;13:15999. doi: 10.1038/s41598-023-42234-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Nanostring RNA gene expression array analyses. (A) Volcano plot identified 93 DEGs between HES1 (+) (n = 5) and HES1 (−) group (n = 4) (p < 0.05), of which 82 DEGs were upregulated and 19 DEGs were downregulated in HES1 (−) group. (B) A heatmap of 52 matrix remodeling and metastasis process-related genes (rows) is shown for 9 samples (columns) including HES1 (−) (blue bar) and HES1 (+) cases (red bar). (C) A heatmap of 46 differentially expressed genes included in the cell proliferation process (rows) for 9 samples (columns) including HES1 (−) (blue bar) and HES1 (+) cases (red bar). (D) The GSVA plot showing that loss of HES1 was positively correlated with the matrix remodeling and metastasis process and negatively correlated with cell proliferation process (*p < 0.05).