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. 2023 Sep 25;13:15999. doi: 10.1038/s41598-023-42234-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Expression of EMT and proliferation markers. (A) Representative immunohistochemistry staining of E-cadherin and the analysis of its aberrant expression associated with HES1 (−) CRCs. (B–D) Representative immunohistochemistry staining of Ki67 (B), RB1 (C) and Cyclin D1 (D). Differential IHC scores were shown below. (E) Poor prognosis associated with low HES1 expression in TCGA CRC dataset.