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. 2023 Sep 25;13:15999. doi: 10.1038/s41598-023-42234-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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HES1 downregulation increased CRC cell migration and EMT marker expression. (A) HES1 expression in SW620 cells decreased by HES1 shRNA (HES1 KD). (B) Migration assays showing the decrease of cell migration in HES1 KD cells. (C) qRT-PCR showing expression of EMT markers in HES1 KD cells vs controls. (D) Increased cellular proliferation in HES1 KD cells by MTT assays. Data shown in (B–D) represents the means ± SD of three to six independent experiments. **p < 0.01; ***p < 0.001.