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Potential roles of HDACs in cardiac myocytes. Class II HDACs repress hypertrophy. Their activity is repressed by signal-dependent phosphorylation. Class I HDACs appear to be prohypertrophic based on the ability of HDAC inhibitors to prevent hypertrophy. Class I HDACs could act by inhibiting prohypertrophic signaling pathways, by inhibiting the expression of growth inhibitory genes or by activating the expression of pro-growth genes.
