Table 1.
Adjusted association between NF-L and sarcopenic determinants
Dependent variable | Handgrip strength | SMI | SPPB score | Gait Speed | Time up and go | |||||
---|---|---|---|---|---|---|---|---|---|---|
Rpartial | p-value | Rpartial | p-value | Rpartial | p-value | Rpartial | p-value | Rpartial | p-value | |
Age (years) | − 0.2644 | < 0.0001*** | − 0.0095 | 0.8493 | − 0.2425 | < 0.0001*** | − 0.1884 | 0.0001*** | 0.0992 | 0.0536 |
Sexe | − 0.7641 | < 0.0001*** | − 0.7359 | < 0.0001*** | − 0.2267 | < 0.0001*** | − 0.2152 | < 0.0001*** | 0.1696 | 0.0009*** |
Number of drugs | − 0.1571 | 0.0016** | − 0.0762 | 0.1265 | − 0.2012 | < 0.0001*** | − 0.1799 | 0.0003*** | 0.1663 | 0.0012** |
Number of concomitant diseases | − 0.01358 | 0.7861 | 0.0357 | 0.4747 | − 0.1687 | 0.0007*** | − 0.1192 | 0.0169*** | 0.1093 | 0.033* |
MMSE | 0.07393 | 0.139 | 0.0815 | 0.1022 | 0.2071 | < 0.0001*** | − 0.1639 | 0.001*** | − 0.1331 | 0.0095** |
Body mass index (kg/m2) | 0.04933 | 0.3238 | 0.6699 | < 0.0001*** | − 0.188 | 0.0001*** | − 0.1946 | 0.001*** | 0.0709 | 0.1682 |
log NF-L (pg/mL) | − 0.1247 | 0.123* | − 0.1095 | 0.0279* | − 0.1747 | 0.0004*** | − 0.2011 | < 0.0001*** | 0.0097 | 0.8514 |