Table 1.

Summary of the results for the whole brain region according to the differences on common DTI-derived metrics.

Method	FA	MD	AD	RD
White matter
MAE $\downarrow$
LAR-DTI	$0.2732\pm 0.0810\ast$	$0.0000\pm 0.0000$	$0.0004\pm 0.0003\ast$	$0.0002\pm 0.0001\ast$
DeepDTI	$0.1349\pm 0.0094\ast$	$0.0000\pm 0.0001$	$0.0002\pm 0.0002\ast$	$0.0001\pm 0.0000\ast$
HADTI-Net	$0.0595\pm 0.0213$	$0.0000\pm 0.0000$	$0.0001\pm 0.0001$	$0.0000\pm 0.0000$
SSIM $\uparrow$
LAR-DTI	$0.2652\pm 0.0818\ast$	$0.6069\pm 0.1191$	$0.2692\pm 0.1024\ast$	$0.2865\pm 0.1078\ast$
DeepDTI	$0.6260\pm 0.0314\ast$	$0.7113\pm 0.1732$	$0.5024\pm 0.1371\ast$	$0.5932\pm 0.1256\ast$
HADTI-Net	$0.8401\pm 0.0574$	$0.7337\pm 0.1479$	$0.7227\pm 0.1038$	$0.7367\pm 0.1243$
Cross-correlation $\uparrow$
LAR-DTI	$0.3941\pm 0.1002\ast$	$0.9170\pm 0.0926$	$0.5511\pm 0.1175\ast$	$0.6016\pm 0.1595\ast$
DeepDTI	$0.7331\pm 0.0633\ast$	$0.9108\pm 0.1432$	$0.7597\pm 0.1810\ast$	$0.8701\pm 0.1009\ast$
HADTI-Net	$0.8980\pm 0.0671$	$0.9372\pm 0.0895$	$0.9019\pm 0.0943$	$0.9291\pm 0.0772$
Grey matter
MAE $\downarrow$
LAR-DTI	$0.3377\pm 0.1022\ast$	$0.0000\pm 0.0000$	$0.0004\pm 0.0002\ast$	$0.0002\pm 0.0001\ast$
DeepDTI	$0.0597\pm 0.0171\ast$	$0.0001\pm 0.0002$	$0.0001\pm 0.0002$	$0.0001\pm 0.0002$
HADTI-Net	$0.0513\pm 0.0061$	$0.0000\pm 0.0000$	$0.0001\pm 0.0000$	$0.0000\pm 0.0000$
SSIM $\uparrow$
LAR-DTI	$0.1414\pm 0.0636\ast$	$0.8787\pm 0.0874$	$0.3989\pm 0.1315\ast$	$0.5761\pm 0.1467\ast$
DeepDTI	$0.6593\pm 0.0592\ast$	$0.8663\pm 0.2063$	$0.7676\pm 0.1800$	$0.8455\pm 0.2031$
HADTI-Net	$0.7295\pm 0.0448$	$0.8047\pm 0.1246$	$0.7474\pm 0.1186$	$0.8003\pm 0.1184$
Cross-correlation $\uparrow$
LAR-DTI	$0.2794\pm 0.0529\ast$	$0.9669\pm 0.0506$	$0.6362\pm 0.1302\ast$	$0.7553\pm 0.1435$
DeepDTI	$0.5268\pm 0.0691\ast$	$0.9341\pm 0.1167$	$0.8303\pm 0.1266$	$0.9230\pm 0.1183$
HADTI-Net	$0.6857\pm 0.0568$	$0.8614\pm 0.1031$	$0.8348\pm 0.1080$	$0.8645\pm 0.1001$

${}^{\ast }$Indicates significantly worse results when compared to HADTI-Net (higher or lower values depending on the metric) with the significance level $\alpha =0.01$.