Table 3.
Serial changes in laboratory profiles and the proportion of patients with LDL-cholesterol level of <70 mg/dL according to diabetes mellitus and treatment strategy.
| Patients with DM |
Patients without DM |
|||||
|---|---|---|---|---|---|---|
| Treat-to-target group | High-intensity statin group | p-value | Treat-to-target group | High-intensity statin group | p-value | |
| At randomization | ||||||
| Total number of patients | 735 | 733 | 1465 | 1467 | ||
| LDL-cholesterol, mg/dL | 78.4 (31.1) | 78.8 (28.8) | 0.76 | 90.4 (32.8) | 91.2 (31.9) | 0.50 |
| Total cholesterol, mg/dL | 145.2 (36.3) | 147.4 (33.4) | 0.24 | 161.5 (37.9) | 162.3 (37.8) | 0.53 |
| Triglycerides, mg/dL | 143.2 (90.1) | 146.9 (87.9) | 0.43 | 136.0 (79.8) | 132.1 (79.8) | 0.18 |
| HDL-cholesterol, mg/dL | 44.4 (11.3) | 44.4 (10.8) | 0.98 | 47.9 (11.4) | 48.2 (11.7) | 0.44 |
| Number of patients with LDL cholesterol level <70 mg/dL | 315 (42.9%) | 298 (40.7%) | 0.42 | 397 (27.1%) | 357 (24.3%) | 0.10 |
| Serum haemoglobin A1c level, % | 7.2 (1.2) | 7.1 (1.1) | 0.11 | 5.9 (0.5) | 5.9 (0.5) | 0.86 |
| At 1-year | ||||||
| Total number of patients | 629 | 633 | 1233 | 1221 | ||
| LDL-cholesterol, mg/dL | 66.6 (20.3) | 64.4 (22.1) | 0.07 | 70.7 (20.6) | 70.7 (22.7) | 0.98 |
| Total cholesterol, mg/dL | 135.9 (27.6) | 138.4 (28.4) | 0.11 | 137.7 (27.4) | 135.9 (26.8) | 0.10 |
| Triglycerides, mg/dL | 135.2 (86.6) | 133.8 (81.3) | 0.78 | 130.3 (74.4) | 128.8 (72.3) | 0.58 |
| HDL-cholesterol, mg/dL | 47.4 (11.9) | 47.4 (11.8) | 0.99 | 47.9 (11.8) | 47.7 (11.9) | 0.50 |
| Number of patients with LDL cholesterol level <70 mg/dL | 395 (62.8%) | 416 (65.7%) | 0.31 | 643 (52.1%) | 676 (55.4%) | 0.12 |
| Serum haemoglobin A1c level, % | 7.2 (1.2) | 7.2 (1.2) | 0.47 | 5.9 (0.5) | 5.9 (0.6) | 0.26 |
| At 2 years | ||||||
| Total number of patients | 550 | 578 | 1104 | 1101 | ||
| LDL-cholesterol, mg/dL | 63.1 (19.9) | 63.0 (23.0) | 0.94 | 68.6 (18.9) | 69.2 (22.0) | 0.47 |
| Total cholesterol, mg/dL | 134.6 (26.8) | 135.9 (27.5) | 0.43 | 137.2 (26.1) | 135.6 (26.0) | 0.14 |
| Triglycerides, mg/dL | 131.2 (80.1) | 130.7 (75.4) | 0.91 | 127.7 (67.4) | 122.5 (69.0) | 0.08 |
| HDL-cholesterol, mg/dL | 47.0 (11.9) | 46.6 (12.0) | 0.53 | 47.9 (11.5) | 47.3 (11.7) | 0.24 |
| Number of patients with LDL cholesterol level <70 mg/dL | 380 (69.1%) | 386 (66.8%) | 0.44 | 625 (56.6%) | 629 (57.1%) | 0.84 |
| Serum haemoglobin A1c level, % | 7.2 (1.2) | 7.2 (1.1) | 0.69 | 5.9 (0.5) | 6.0 (0.6) | 0.36 |
| At 3 years | ||||||
| Total number of patients | 532 | 555 | 1028 | 999 | ||
| LDL-cholesterol, mg/dL | 63.6 (19.9) | 62.9 (21.7) | 0.54 | 69.6 (21.6) | 70.1 (23.3) | 0.63 |
| Total cholesterol, mg/dL | 133.3 (26.9) | 137.3 (28.7) | 0.02 | 136.3 (26.6) | 136.0 (26.2) | 0.80 |
| Triglycerides, mg/dL | 128.9 (71.5) | 126.9 (84.7) | 0.66 | 128.0 (73.9) | 126.9 (79.5) | 0.74 |
| HDL-cholesterol, mg/dL | 45.7 (11.2) | 46.9 (11.6) | 0.09 | 46.7 (11.6) | 47.1 (11.4) | 0.41 |
| Number of patients with LDL cholesterol level <70 mg/dL | 353 (66.4%) | 378 (68.1%) | 0.58 | 555 (54.0%) | 549 (55.0%) | 0.70 |
| Serum haemoglobin A1c level, % | 7.2 (1.2) | 7.1 (1.1) | 0.11 | 6.0 (0.5) | 6.0 (0.5) | 0.86 |
Data are presented as means (standard deviations) or number (%). DM, diabetes mellitus; LDL, low-density lipoprotein; HDL, high-density lipoprotein.