Table 3.
Treatment-related adverse events in all treated patients (N = 49).
| Adverse events | All patients | Grade 1–2 | Grade 3–4 |
|---|---|---|---|
| HFS reaction | 28 (57) | 25 (51) | 3 (6) |
| Cholesterol elevation | 23 (47) | 23 (47) | 0 |
| Proteinuria | 21 (43) | 21 (43) | 0 |
| Triglyceride elevation | 20 (41) | 19 (39) | 1 (2) |
| Hypertension | 19 (39) | 14 (29) | 5 (10) |
| TSH elevation | 17 (35) | 17 (35) | 0 |
| Diarrhoea | 16 (33) | 16 (33) | 0 |
| Urine occult blood | 15 (31) | 15 (31) | 0 |
| Faecal occult blood | 14 (29) | 14 (29) | 0 |
| Hypothyroidism | 13 (27) | 13 (27) | 0 |
| Arthralgia | 13 (27) | 13 (27) | 0 |
| Pharyngalgia | 10 (20) | 10 (20) | 0 |
| ALT elevation | 9 (18) | 9 (18) | 0 |
| AST elevation | 9 (18) | 9 (18) | 0 |
| Leukopenia | 9 (18) | 9 (18) | 0 |
| Hyperuricemia | 8 (16) | 8 (16) | 0 |
| Serum creatinine elevation | 8 (16) | 8 (16) | 0 |
| Neutropenia | 7 (14) | 6 (12) | 1 (2) |
| Voice hoarse | 7 (14) | 7 (14) | 0 |
| Gingivitis | 6 (12) | 6 (12) | 0 |
| Abdominal pain | 6 (12) | 6 (12) | 0 |
| Headache | 6 (12) | 6 (12) | 0 |
| Hyperbilirubinemia | 6 (12) | 5 (10) | 1 (2) |
| Fatigue | 5 (10) | 5 (10) | 0 |
| Hypokalemia | 5 (10) | 5 (10) | 0 |
| Oral mucositis | 5 (10) | 5 (10) | 0 |
| Dizziness | 5 (10) | 5 (10) | 0 |
| Nausea | 5 (10) | 5 (10) | 0 |
| Thrombocytopenia | 5 (10) | 5 (10) | 0 |
Data presented as n (%). Each patient is counted once for a specific adverse event. Only the highest grade of a given adverse event is reported for each patient. Listed are events of any grade reported in at least 10% of patients.
HFS = hand-foot skin. TSH = thyroid stimulating hormone. ALT = alanine aminotransferase. AST = aspartate aminotransferase.