Table 3.
Individual placental lesions in women affected by early-onset FGR
|
Placental findings |
n/Total (%) |
Preeclampsia and early-onset FGR (n=49) |
Normotensive early-onset FGR (n=36) |
p-value |
|
Maternal vascular malperfusion |
||||
|
▪ Infarctions |
57/85 (67.05%) |
41/49 (83.7%) |
16/36 (44.4%) |
0.015 |
|
→ of which late infarctions |
38/85 (44.6%) |
28/49 (58.1%) |
10/36 (27.8%) |
<0.001 |
|
▪ Retroplacental hemorrhage |
11/85 (12.9%) |
6/49 (12.2%) |
5/36 (13.9%) |
0.53 |
|
▪ Accelerated villous maturation |
6/85 (7.05%) |
4/49 (8.2%) |
2/36 (5.6%) |
0.49 |
|
Syncytial knots |
||||
|
▪ Mildly increased (15–30%) |
34/85 (40.0%) |
18/49 (36.7%) |
16/36 (44.4%) |
0.50 |
|
▪ Severely increased (≥30%) |
35/85 (41.2%) |
25/49 (51.0%) |
10/36 (27.8%) |
0.04 |
|
▪ Massive perivillous fibrin deposition |
7/85 (8.2%) |
3/49 (6.1%) |
4/36 (11.1%) |
0.45 |
|
Fetal vascular malperfusion |
||||
|
▪ Thrombosis |
10/85 (11.7%) |
5/49 (8.2%) |
5/49 (16.7%) |
0.31 |
FGR: Fetal growth restriction; n: No. of cases