Figure 1.

Fever and respiratory changes associated with H5N1-mediated disease in macaques

Macaques were infected with aerosolized H5N1 across a range of doses to understand the relationship between dose, disease, and outcome. Closed symbols are macaques that survived infection; open symbols are macaques that succumbed to infection.

(A) show daily median residual temperatures (difference between actual and predicted temperatures) as recorded by telemetry for individual macaques separated by dose range.

(B–D) changes in respiratory parameters measured by plethysmograph on days 2, 4, 7, 11, and 14. Graphs show percent change from baseline in (B) respiratory rate, (C) expiratory time, and (D) inspiratory time.