Figure 5.

aQIV protects against death but not severe respiratory disease after lethal aerosol H5N1 challenge

(A) Survival after challenge over 15 days; (B–E), (G) black lines & circles denote mock-vaccinated macaques and red lines & triangles denote aQIV-vaccinated macaques; open symbols are macaques that succumbed to infection.

(B–G) (B) Median daily deviation in body temperature from predicted for mock-vaccinated (left graph) and aQIV-vaccinated (right graph) macaques; (C) % change in respiratory rate compared to baseline from predicted for mock-vaccinated (left graph) and aQIV-vaccinated (right graph) macaques; (D) Day 2 post-challenge change in inspiratory time (x axis) vs. respiratory rate (y axis) for all macaques; the solid line is the linear regression analysis and dotted lines show the 95% confidence intervals; (E) differences between mock-vaccinated and aQIV-vaccinated macaques in average temperature elevation, maximum temperature deviation, respiratory rate at day 2, and viral titer in BAL at day 4; lines show the average and standard deviation for each group, ∗p < 0.05, ∗∗p < 0.01 by Welch’s t test; (F) radiographs of representative mock-vaccinated and aQIV-macaques prior to challenge and at day 4 post-challenge; (G) correlation of H5N1-neutralizing antibody at week 6 post vaccination and changes in day 4 BAL virus titer, average body temperature elevation, and day 2 respiratory rate. The solid line is the linear regression analysis for each graph.