. 2023 Sep 6;26(10):107830. doi: 10.1016/j.isci.2023.107830

Table 2.

Challenge doses, outcome, and febrile responses after aerosol challenge of control and aQIV-vaccinated macaques with lethal H5N1

Group	Animal ID	Dose^a	TTD^b	Fever
Group	Animal ID	Dose^a	TTD^b	ΔT Max^c	Duration^d	Severity^e	Ave Elev^f
Control	290-20	5.58	4	2.78	57.25	98.93	1.73
	295-20	5.67	15	3.39	147.50	253.91	1.72
	308-20	5.93	4	3.59	77.25	156.58	2.03
	311-20	5.38	3	3.69	64.75	145.71	2.25
	25-21	5.60	3	3.40	60.50	127.61	2.11
	26-21	6.41	15	2.98	157.00	201.09	1.28
	Median	5.63	4.00	3.40	71.00	151.14	1.88
aQIV	291-20	5.40	15	2.98	98.50	158.01	1.60
	292-20	5.74	15	2.97	119.50	170.53	1.43
	307-20	6.09	15	2.83	111.00	174.04	1.57
	309-20	5.65	15	2.52	99.00	126.17	1.27
	24-21	5.99	15	3.16	119.50	145.83	1.22
	21-21	5.33	15	2.83	117.00	134.41	1.15
	Median	5.70	15.00	2.90	114.00	151.92	1.35

Dose = inhaled dose, in log10 pfu.

TTD = time to death.

ΔTmax = maximum deviation from predicted temperatures.

Duration = hours of significant temperature deviation from predicted.

Severity = sum of significant temperature deviations, adjusted to hours.

Ave Elev = average elevation in temperature, the product of dividing Severity by Duration.