Figure 1.

AAV-BDNF gene therapy improves body composition in female Magel2-null mice

(A) Vector schematics. (B) Body weight. (C) Percent change in body weight. (D) Baseline relative fat mass. (E) Baseline relative lean mass. (F) Relative fat mass at 6 weeks post AAV injection. (G) Relative lean mass at 6 weeks post AAV injection. Data are means ± SEM. Sample size: n = 6 per group. ∗ or #p < 0.05, ∗∗ or ##p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001. For time course measurements, # symbols denote WT YFP vs. Magel2-null YFP and ∗ symbols denote Magel2-null YFP vs. Magel2-null BDNF.