Figure 5.
AAV-BDNF gene therapy induces a reversal in microglial activation markers in female Magel2-null mice
(A) Gene expression of putative microglia markers; all listed genes were identified as DEGs. (B) IPA activation of microglia canonical pathway. DEGs were identified using the following thresholds: log2[fold change] < −0.585 or >0.585 (corresponding with a fold change of 1.5), Q-value (or a false discovery rate p value) < 0.05. Sample size: WT YFP n = 6, WT BDNF n = 4, Magel2-null YFP n = 6, Magel2-null BDNF n = 6.