Figure 8.

CircSOBP treatment produces effective tumor-reactive CTL and NK cell responses

(A and B) IF staining analysis of circSOBP and Poly(I:C) treatment alone or in combination increased infiltration of NK cells and CD8⁺ T cells into the tumor. Values of control were used to normalize and quantify the rate of cell positivity. Scale bar, 20 μm.

(C) Increased expression of granzyme K in tumor-infiltrating CD8⁺ T cells or NK cells using immunofluorescence (IF) staining. Scale bar, 20 μm. All statistics of error bars, S.E.M. from three independent experiments. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001 by two-tailed Student’s t test. Normalized by the value of the control group.