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. 2023 Sep 13;86(9):2151–2161. doi: 10.1021/acs.jnatprod.3c00363

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© 2023 The Authors. Published by American Chemical Society and American Society of Pharmacognosy

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CBD alters the expression of proteins involved in cell proliferation. (A) Prostate cancer cells (DU145, PC-3) were treated with IC₅₀ doses of CBD for 48 h. Expression of CDK2, CDK4, cyclin D3, and CDK1 was measured using Western blotting. (B) PC-3 cells were treated with an IC₅₀ dose of CBD for 48 h. AKT phosphorylation was measured by using Western blotting. (C) DU145 cells were treated with an IC₅₀ dose of CBD for 48 h. AKT phosphorylation was measured using Western blotting. Images of representative blots are shown. Data are represented as mean ± SD calculated from at least three independent experiments. *p < 0.05, ***p < 0.001 compared to the vehicle control.