Altindis 2008.

Methods	RCT, 2 parallel groups
Participants	Number: 40 participants Country: Turkey Surgery: lower abdominal surgery Age: 21 to 56 years ASA: I or II Other inclusion criteria: general anaesthesia Exclusion criteria: history of hypertension, ischaemic heart disease or conduction disturbance; history of alcohol or drug abuse; use of beta‐adrenoreceptor blockers, monoamine oxidase inhibitor within 2 weeks; impaired hepatic or renal function; hypersensitivity to opioids or dexmedetomidine
Interventions	Meperidine 0.25 mg/kg intravenous bolus and dexmedetomidine 0.5 µg/kg in 50 mL of saline solution infused during the 10 minutes before the end of surgery vs Meperidine 0.25 mg/kg intravenous bolus and 50 mL of saline solution infusion during 10 minutes before the end of surgery All participants: Premedication: 10 mg 2 hours before surgery After surgery: PCA during 24 hours after surgery. PCA settings were as follows: meperidine 5 mg plus dexmedetomidine 10 µg bolus dose for Group I, and meperidine 5 mg bolus dose for Group II
Outcomes	Verbal rating score for pain (0 to 3) Total meperidine consumption Time to discharge from PACU Postoperative sedation (0 to 3) Number of participants with postoperative vomiting Hemodynamic data
Notes	Study authors contacted to clarify types of surgery. No reply